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Publications Relating to the TheraKan™, Cell Culture and Tissue Analysis

Studies involving the TheraKan    system

Gage Brummer, Wei Fang, Curtis Smart, Brandon Zinda, Nadia Alissa, Cory Berkland, David Miller, Nikki Cheng,

CCR2 signaling in breast carcinoma cells promotes tumor growth and invasion by promoting CCL2 and suppressing CD154 effects on the angiogenic and immune microenvironments, Read more

Oncogene. 2020 Mar;39(11):2275-2289. doi: 10.1038/s41388-019-1141-7. Epub 2019 Dec 11.PMID: 31827233, PMC7071973

Jacob New,  Vikalp Vishwakarma, Dhruv Kumar, .Vusala Snyder, Levi Arnold, Emily Nissen; Qinting Hu; Nikki Cheng,  Yelizaveta Shnayder,. Kiran Kakarala,  Terance Tsue, Douglas Girod,  Sufi Thomas.  

Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Read more

Scientific Reports.2018. 8:12163 | DOI:10.1038/s41598-018-29683-1

Wei Bin Fang, Min Yao, Gage Brummer, Nabil Alhakamy, Cory Berkland, Nikki Cheng

Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment. Read More

Oncotarget. 2016 Jun 7. doi: 10.18632/oncotarget.9885. [Epub ahead of print] PubMed PMID: 27283985

Studies involving 3D cell culture/ ex vivo tissue culture

Qingting Hu, Megan Meyers, Wei Fang, Min Yao, Gage Brummer, Justin Hawj, Nikki Cheng

Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion. Read more

Biol Open. 2019 Jun 28;8(7) DOI:10.1242/bio.040873 PMID:31208996. PMC6679398

Min Yao, Wei Fang, Curtis Smart, Qingting Hu, Shixia Huang, Nehemiah Alvarez, Patrick Fields, Nikki Cheng.

CCR2 chemokine receptors enhance growth and cell cycle progression of breast cancer cells through SRC and PKC activation. Read more

Molecular Cancer Research, DOI: 10.1158/1541-7786.MCR-18-0750 Published OnlineFirst. November 16, 2018. PMID:30446625 PMCID: PMC6359961

Shira Bernard, Megan Myers, Wei Bin Fang, Brandon Zinda, Curtis Smart, Diana Lambert, An Zou, Fang Fan, Nikki Cheng.

CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. Read more

Journal of Mammary Gland Biology and Neoplasia 2018 Aug 9. doi: 10.1007/s10911-018-9407-1. [Epub ahead of print]. PMID: 30094610

Wei Bin Fang, Min Yao, Iman Jokar, Nabil Alhakamy, Cory Berkland, Nikki Cheng

The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells. Read More   

Breast Cancer Research and Treatment.2015. Apr;150(2):309-20 PMID:25744294

Studies involving data analysis on human and animal tissues

Gage Brummer, Diana S. Acevedo, Mike Portsche, Qingting Tina Hu,  Wei Bin Fang, Min Yao, Kyle Warren,  Brandon Zinda, Yan Hong, Fariba Behbod, Nikki Cheng

Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms. Read more

Molecular Cancer Research. 2018 Feb;16(2):296-308. doi: 10.1158/1541-7786.MCR-17-0308. Epub 2017 Nov 13. PMID: 29133591. PMCID: PMC5805627

Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng

Continuous delivery of neutralizing antibodies elevate CCL2 levels in mice bearing MCF10CA1d breast tumor xenografts. Read more

Translational Oncology. 2017 vol 10. 734-743  PMID:28734227 PMCID: PMC5521028 DOI:10.1016/j.tranon.2017.06.009

Min Yao, Elaine Yu, Diana Lambert, Vincent Staggs, Fang Fan, Nikki Cheng.  

Elevated expression of Chemokine C-C Ligand 2 in stroma is associated with recurrent Basal-like breast cancers. Read more.

Modern Pathology .2016 2016 Aug;29(8):810-23. PMID:27125354 DOI:10.1038/modpathol.2016.78

An Zou, Diana Lambert, Henry Yeh, Ken Yasukawa, Fariba Behbod, Fang Fan, Nikki Cheng

Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins. Read more

BMC Cancer 2014. 14 (781). PMID:25344051 PMCID: PMC4221705 DOI:10.1186/1471-2407-14-781

Wei Bin Fang, Diana Lambert, Iman Jokar, Prasanthi Dendukuri, Nikki Cheng

CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms. Read more

Journal of Biological Chemistry. 2012, 287(43),36593-608. PMID: 22927430 PMCID: PMC3476325 DOI:10.1074/jbc.M112.365999

Wei Bin Fang, Iman Jokar, Anna Chytil, Harold L. Moses, Tye Abel, Nikki Cheng

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Read More

Clinical and Experimental Metastasis, 2011 28(4), 351-366. PMID: 21374085


Stacy Hembruff, Iman Jokar, Li Yang, Nikki Cheng

CCL2 derived from TGF-b signaling deficient fibroblasts regulates mammary tumor progression through macrophage dependent and independent mechanisms. Read More

Neoplasia, 2010 May;12(5):425-33. (cover issue)

Nikki Cheng, Anna Chytil, Alison Joly, Yu Shyr, Harold L. Moses 

Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Read More

Cancer Research, 2007 May 15;67(10):4869-77





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